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Psychedelic drug Wikipedia Tryptamine Psychedelics all inhibited dorsal raphe cell firing (Aghajanian et al., 1970; Aghajanian and Hailgler, 1975; deMontigny and Aghajanian, 1977), leading Aghajanian and Hailgler to hypothesize that this suppressant effect on raphe cell firing might be the underlying basis for the action of psychedelics. The reticular nucleus is known to regulate the flow of information between the thalamus and the cortex and sends inhibitory projections into the thalamus, apparently serving a negative-feedback regulatory role in thalamic function. It has been proposed to serve as a sort of “searchlight” of attention (Crick, 1984; Sherman and Guillery, 1996) and to control elements of signal to noise or the quality of information being sent to the cortex . It is clear that specific ligands interact with the 5-HT2A receptor to activate the PLC and PLA2 pathways to different extents. At the rat 5-HT2A receptor expressed in NIH3T3 cells, for example, LSD, DOB, psilocin...